International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity1
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چکیده
Marc A.T. Teunis, Sander W. Spiekstra, Mieke Smits, Els Adriaens, Tobias Eltze, Valentina Galbiati, Cyrille Krul, Robert Landsiedel, Raymond Pieters, Judith Reinders, Erwin Roggen, Emanuela Corsini, Susan Gibbs* 1 University of Applied Sciences, Utrecht, The Netherlands; 2 Dept. Dermatology, VU University Medical Centre, Amsterdam, The Netherlands; 3 Adriaens Consulting, Statistical and Scientific Consultancy, Aalter, Belgium; 4 BASF SE, Ludwigshafen, Germany; 5 Laboratory of Toxicology, DiSFeB, Università degli Studi di Milano, Italy; 5 TNO, Zeist, The Netherlands; 6 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; 7 3Rs Management and Consultancy, Denmark; 8 Dept. Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), The Netherlands
منابع مشابه
International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity.
This study describes the international ring trial of the epidermal-equivalent (EE) sensitizer potency assay. This assay does not distinguish a sensitizer from a non-sensitizer, but may classify known skin sensitizers according to their potency. It assesses the chemical concentration resulting in 50% cytotoxicity (EE-EC50) or the 2-fold increase in IL-1α (IL-1α2x). Four laboratories received 13 ...
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تاریخ انتشار 2014